For demonstrating my polypaint workflow, I’ll be using a 3D character I created based on a 2D sketch by avvou.
The polypaint workflow is the quicker and easier workflow of the two, which simply involves painting the ZBrush sculpt using polypaint. For those who are not familiar with polypainting, it involves painting on a 3D mesh without having to first assign a texture map. You will require dense enough topology to work with polypaint. Some ZBrush features to use would be auto-masking, various alphas and brushes, and the layer stack.
I used black and white values to paint tattoos along the nose, lips, ears, and eyelids. This allowed me to easily change the overall colors in Toolbag (shown later). But feel free to use colors here to paint an elaborate polypaint for your mesh.
Once you’ve polypainted your mesh, export the model from ZBrush. I usually export an .obj file and use the default settings from ZBrush. That combination has never given me any problems, however, be aware if you’re using layers, make sure that none are recording during the export process.